Lumbar Puncture in Thrombocytopenia: The Floor Is Not Firm
نویسندگان
چکیده
Objective Lumbar puncture (LP) is a diagnostic procedure that accesses the spinal subarachnoid space to measure opening pressure of cerebrospinal fluid (CSF) and obtain samples CSF for analysis. Although commonly performed, LPs are associated with risk morbidity mortality. In addition, thrombocytopenia thought increase LP complications, particularly bleeds. This study compares rates complications among patients who received without in hopes establishing more evidence-based platelet thresholds an LP. Methods The TriNetX multi-institutional electronic health record database was used perform retrospective propensity score-matched analysis clinical outcomes two cohorts underwent - those (defined as level 10,000-50,000 platelets {plts}/μL) thrombocytopenia. interest were new occurrence subdural hematoma, epidural hemorrhage, receipt blood patch, onset paralysis, requirement decompression. Results developing bleed following 1.496% (42 2,808) cohort versus 1.09% (31 2,843) difference, ratio, odds ratio from these experiencing insignificant at 0.05. receiving patch 7.844% compared 1.421% between 5.906, significant 0.05 (95% CI: 4.213-8.279). There no difference cohorts’ paralysis or requiring decompression Conclusion support recent findings against conventional count prior LP, it observed present incidence post-LP bleeding 30 days after not counts below guideline threshold 50,000 plts/μL. Patients also significantly likely require develop paralysis. However, increased likelihood
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ژورنال
عنوان ژورنال: Cureus
سال: 2023
ISSN: ['2168-8184']
DOI: https://doi.org/10.7759/cureus.42019